Technical Services Department

Surgical Animal Models  /  Animal Models of Human Disease  /  Contract Research  / Tissues and Organs

Zivic Laboratories' Technical Services Department provides a vast array of products and services designed to aid the international research and pharmacological communities.  Harnessing nearly 40 years of experience with laboratory animal surgery, Zivic Laboratories has developed and commercialized many technosurgically-designed rodent animal models used to elucidate the mechanisms and pathways of numerous human disease processes.  We perform cannulations along with endocrine, vascular and nervous system modifications that, in turn, aid in clarifying the pathways of disease processes.  By allowing our staff to prepare your animals or tissues, you can save both time and money needlessly spent laboring to develop specific techniques or reliable results.  Let our experienced staff aid you in your efforts, lending able and expert hands to assure that your time and energies are most appropriated directed. 

Below you will find a sampling of some of our standard services, but please note that we are not limited to what follows.  Feel free to write, call, or fax your protocol or thoughts and our staff will gladly evaluate them and provide a cost estimate.  Furthermore, our IACUC can review and, upon acceptance, endorse your proposal.

Relying on nearly 40 years of time-tested expertise, Zivic Laboratories, Inc. maintains the largest commercial library of standard surgical animal modifications. In addition to standard procedures, our surgeons are capable of performing innumerable other complex or personalized modifications to meet your specific needs.

Standard Surgical Models

-       Cannulations

-       Electrolytic Lesions

-       Endocrine Modifications

-       Hepatic and Gastro-Intestinal Modifications

-       Implantations and Injections

-       Neo-natal Procedures

-       Nerve Sections

-       Neurotoxic Chemical Lesions

-       Reproductive Modifications

-       Sensory Modifications

-       Stereotaxic Procedures

-       Vascular Modifications

-       Custom / Other

From the 6-OHDA model for Parkinson's Disease to the Middle Cerebral Artery Occlusion (MCAO) model for focal cerebral ischemia, a myriad of available models and model development services to aid in your academic or pre-clinical research needs.

Animal Models of the Following Human Diseases are Routinely Performed

-       Amnesia / Learning Impairment

-       Circadian Arrhythmicity

-       Cerebral Ischemia (stroke)

-       Cerebral Hemorrhage 

-       Diabetes Mellitus

-       Depression

-       Emphysema

-       Heart Attack (Myocardial Infarction)

-       Huntington's Disease

-       Parkinson's Disease

-       Schizophrenia

-       Split-Brain

-       Stroke

-       Vascular Restinosis (balloon injury)

Toxicology studies, diet related studies, hepatocyte preparation, gene expression analysis, tissue harvest, microarray services…let us take away the burden of dosing, holding, and preparing your laboratory animals. We can perform entire experiments or specific segments of your protocol, all the while gathering data according to your specifications.

Standard In-Vivo Contract Research Services

-       Toxicology Studies

-       Efficacy Studies

-       Studies Upon Animal Models of Human Disease

-       Diet/Nutrition Modification Studies

-       Holding/Breeding Animal Colonies

-       Pre-natal Studies (involving ZL precisely-timed pregnant rats^tm)

-       Re-derivation

-       In-House Dosing, Holding, and Tissue Harvest

-  Studies Involving ZL Techno-Surgical Animal Models of Human Disease (e.g. Myocardial infarction model of heart attack, focal/global brain ischemia models of stroke, 6-0HDA Lesion Model of Parkinson's Disease)

Custom preparations using the latest RNA preservation techniques. Freshly extracted from all sizes, ages, and regions of rats or mice; flash frozen tissues, perfusions, brain tissue slices and punches, etc.

Freshly Prepared Tissues and Organs

-       Tissues and Organs Are Prepared Per Request to Assure Freshness

-       Large and Small Orders Accepted

-       Lead Time (i.e. time from placement of order to receipt of tissues) Generally < 1 Week

-       Special Holding or Dosing Prior to Tissue Harvest

-       LN2 Flash Freezing

-       RNA Later

-       Discrete Brain Nuclei Isolation, Extraction, and Preparation

-       In-House Dosing, Holding, and Tissue Harvest

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